【摘要】 目的:研究复极末期牵张家兔左心室对心脏电活动的影响及其机制。方法:应用心室压力钳技术观察复极末期牵张刺激(120mmHg,50ms)对家兔心脏节律的影响,并用链霉素(500μmol/L)对其机制进行探讨。结果:复极末期牵张刺激引起心律失常的发生(P<0.05),链霉素则抑制复极末期牵张的致心律失常作用(P<0.05)。结论:利用心室压力钳技术对家兔左心室施加复极末期牵张刺激可导致心律失常的发生,而链霉素可抑制这种致心律失常作用,说明牵张激活离子通道在牵张刺激引起的心律失常中可能发挥作用。更多还原

【Abstract】 Aim:To observe the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity,and to investigate its possible mechanisms.Methods:Stretch(120 mmHg,50 ms)was applied in the end of action potential by the pressure-clamp technique to observe if there would be any changes in rabbit cardiac activity and streptomycin(500 μmol/L)was used to identify the mechanism.Results:Stretch in the end of action potential caused arrhythmia(P<0.05)and streptomycin blocked the above effect(P<0.05).Conclusion:Streptomycin could block the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity,which indicates that stretch-activated ion channels involve it.更多还原