【摘要】 目的了解江苏省无锡市吸毒人群丙型肝炎病毒(HCV)感染现状及其特点,为制订相应的干预措施提供科学依据。方法对无锡市戒毒门诊应用美沙酮维持治疗(MMT)794名吸毒者进行面对面问卷调查,并采静脉血检测抗-HCV抗体。结果794名吸毒者中,总抗-HCV阳性率为85.6%。调查吸毒方式的有效应答者753人,其中静脉注射吸毒者90.7%,抗-HCV阳性率为92.5%,高于非静脉吸毒者的21.4%,差异有统计学意义(χ2=265.40,P<0.001),也高于肌内/皮内注射的42.9%、烫吸者的20.0%和口服吸毒者的18.2%(趋势性χ2=256.16,P<0.001)。调查共用吸毒器具的有效应答者617人,其中528人共用注射器具,占85.6%,HCV感染率为95.5%。直接共用注射器具307人,占58.1%,HCV感染率为95.8%。间接共用注射器具510人(占96.6%),HCV感染率为95.3%。未共用注射器具者的HCV感染率为24.7%。吸毒和静脉注射吸毒的平均年限分别为(9.84±2.87)和(4.96±3.12)年。有5名以上性伴的吸毒人群HCV感染率为88.5%,高于只有单个性伴者的80.8%(χ2=5.08,P=0.024)。结论无锡市戒毒门诊吸毒人群HCV感染率高,相关危险行为普遍存在。更多还原

【Abstract】 Objective To describe the characteristics of HCV infection among drug users of Wuxi,Jiangsu,and provide baseline data for valid intervention.Methods Face-to-face interview using detailed questionnaire was conducted amongst 794 drug users in the methadone maintenance therapy(MMT) clinic of Wuxi,and blood sample was collected and tested for HCV antibody.Results The overall anti-HCV antibody-positive rate was 85.6%,while the rate was 92.5% among 683 IDUs,significantly higher than that of NIDUs(21.4%,χ2=265.40,P<0.001),and also higher than those users of intramuscularly/intradermal addicts(42.9%),syringe addicts(20.0%) and oral addicts(18.2%)(χ2 for trend=256.16,P=0.000).Of 617 users,528 individuals(85.6%) who shared syringes had a higher HCV infection rate(95.5%) compared to those who do not(24.7%),while HCV infection rate was 95.8% among direct syringe sharers(307,58.1%) and 95.3% among indirect ones(510,96.6%).Average durations of drug use and intravenous drug use were 9.84±2.87 and 4.96±3.12 years,respectively.A significantly higher HCV infection rate was found among drug users who have more than 5 sex partners,compared to those who have single sex partner.Conclusion High HCV infection rate was observed among drug users in MMT clinic of Wuxi,and behaviors at high risk were commonly identified.HCV serological and behavior monitoring shoud be applied in the MMT programs,and strategies and measures for comprehensive intervention should be implemented to reduce HCV infection rate and control the transmission from the source population to the general population.更多还原