【摘要】 目的分析泌尿道感染(UTI)病原菌对多类抗生素耐药的相关性,为选择有效抗生素提供依据。方法收集湖北省细菌耐药监测网15所三级甲等医院患者中段尿样分离的病原菌,按统一方法进行药敏试验,用SAS 6.0软件和WHONET 5.3软件进行统计分析。结果病原菌以革兰阴性菌为主,对不同类抗生素的耐药存在广泛而显著的正相关性,并且对多类抗生素的耐药率不断上升。仅呋喃妥因耐药与其他类抗生素耐药的相关性较弱或无相关性,其耐药率较低而稳定。革兰阴性菌对复方新诺明与环丙沙星、氨苄西林、庆大霉素、氯霉素、四环素耐药,环丙沙星与氨苄西林、庆大霉素耐药呈正相关,其r值在0.32~0.44之间,均P<0.001;革兰阳性菌对环丙沙星、复方新诺明、克林霉素、红霉素、庆大霉素中任2种耐药的均呈正相关r值在0.22~0.39,表明革兰阳性菌对这些药物可能存在连锁耐药。结论呋喃妥因可成为经验性治疗泌尿道感染的优选药物。更多还原

【Abstract】 Objective To generalize a theoretically scientific basis on empirical antimicrobial selection for urinary tract infections(UTI),we analyzed correlative resistance of uropathogens to antibiotics of types.Methods Uropathogens of UTI patients were collected from 15 tertiary grade A hospitals in Hubei Antimicrobial Resistance Surveillance Network,and then antimicrobial susceptibility testing was done on uniformity project.Related statistical analysis were made with softwares SAS 6.0 and WHONET 5.3.Results Gram negative bacteria was the most frequently uropathogen.There was generally significant positive correlation between resistance to one antibiotic and to another.Moreover,did rise the high resistance rates of either gram negative strains or gram positive ones to many tested antibiotics.Only nitrofurantoin resistance of low and stable rates had either the faintest or no significant correlation with resistance to any other antibiotic.Conclusion Nitrofurantoin should be the preferred agent for empirical UTI treatment.更多还原