【摘要】 目的探讨血清铁蛋白与原发性高血压是否存在关联,为高血压病因研究提供基础依据。方法采用病例对照研究方法,以黑龙江省电力医院健康检查中心诊断的高血压患者及非高血压者各78人为调查对象,测量血压、身高、体重、腰围、臀围及对吸烟、饮酒的调查。现场采集空腹静脉血并分离血清,检测血脂、空腹血糖、血清铁蛋白等指标。统计分析采用SAS 9.1统计软件,分析上述指标在高血压组和非高血压组人群中的差异。结果年龄、性别、吸烟率和饮酒率在高血压组与非高血压组的差异均无统计学意义(P>0.05)。高血压组的甘油三酯(TG)、低密度脂蛋白胆固醇(LDL)水平均显著高于非高血压组(P<0.01)。高血压组空腹血糖、体质指数(BMI)和腰臀比(WHR)均高于非高血压组(P<0.01)。单因素分析结果显示,血清铁蛋白与原发性高血压、收缩期高血压、舒张期高血压均有关(P<0.05),OR值分别为3.41,2.40,2.57。使用多因素Logistic回归分析调整年龄、性别等混杂因素影响后,血清铁蛋白与原发性高血压、舒张期高血压差异仍有统计学意义,OR值分别为2.78,2.60。血清铁蛋白与收缩期高血压无关联。结论血清铁蛋白与原发性高血压、舒张期高血压相关联,但与收缩期高血压无关联。更多还原

【Abstract】 Objective To explore the association between essential hypertension and serum ferritin and lay a foundation for etiological study of hypertension.Methods The population of Heilongjiang Newspaper Office were selected as subjects to conduct case-control study(case:76;control:76).All subjects were interviewed with questionnaire and measured for blood pressure,stature,weight,waist circumference,hip circumference and investigated for risk factors of life style(smoking and drinking).Blood specimens were collected for detecting serum lipid,fasting plasma glucose,serum ferritin.All data were analyzed with SAS 9.1 software.Results There was no significant difference for age and gender between the hypertensives and normotensives(P>0.05).The exposed proportion of alcohol drinking and smoking had no significant difference in two groups.The average levels of TG,LDL-c in hypertensives were higher than those in the normotensives.Both the body mass index(BMI) and ratio of waist to hip circumference(WHR) were significantly higher in the hypertensives than those in the normotensives(P<0.01).The level of fasting plasma glucose(FPG) were higher in the hypertensives than those in the normotensives.Data from univariate analysis showed serum ferritin was related to essential hypertension,systolic hypertension and diastolic hypertension,ORs were 3.41,2.40,2.57 respectively.After adjusting for confounding factors by logistic regression,serum ferritin was still associated with essential hypertension and diastolic hypertension,ORs were 2.54,2.49 respectively,but not with systolic hypertension.Conclusion The study confirmed that serum ferritin was related to essential hypertension and diastolic hypertension,but not systolic hypertension.更多还原