【摘要】 目的:分析雌、孕激素受体(ER、PR)在上皮性卵巢肿瘤中的表达情况,探讨其与上皮性卵巢肿瘤发生、发展的关系,明确ER、PR在上皮性良、恶性卵巢肿瘤以及上皮性卵巢恶性肿瘤中不同的临床分期、病理分级、病理类型中的表达,从而对上皮性卵巢肿瘤的诊断、内分泌及基因治疗提供依据,以利于制定个体化的治疗方案。方法:对60例上皮性卵巢肿瘤患者病理切片采用免疫组化SP法测定ER、PR;采用SPSS软件χ2检验、四格表确切概率法进行统计学处理。结果:①在上皮性卵巢良性肿瘤(22例)中ER阳性率27.27,PR阳性率22.72,阳性率较低;在上皮性卵巢恶性肿瘤(38例)中的阳性率较高(ER76.32、PR71.05),两者比较,χ2=13.79、χ2=13.07,P<0.01,均有显著性差异。②在上皮性卵巢恶性肿瘤中不同临床分期ER、PR的表达不同,随着临床期别的上升ER、PR的阳性率呈下降趋势。早(Ⅰ、Ⅱ)、晚(Ⅲ、Ⅳ)期比较,四格表确切概率法P>0.05,无显著性差异。③在上皮性卵巢恶性肿瘤中ER、PR在不同的病理分级中的阳性表达率不同,在高分化组的阳性率最高,在低分化组阳性率最低,P>0.05,无统计学意义。④在上皮性卵巢恶性肿瘤中不同病理类型的ER、PR表达不同,浆液性(21例)与粘液性(15例)肿瘤均呈高表达,但无显著性差异,P>0.05。结论:①ER、PR的阳性表达在上皮性卵巢良、恶性肿瘤之间有显著性差异。在上皮性良性肿瘤中呈低表达,而在上皮性恶性肿瘤中呈高表达。②ER、PR阳性表达在上皮性卵巢恶性肿瘤不同的临床分期、病理分级、病理类型中的表达不同,但无显著性差异。③临床工作中通过对它们的评价制定个体化治疗方案,指导治疗、判断预后。更多还原

【Abstract】 Objective:To analyze the expression of estrogen receptor(ER) and progesterone receptor(PR) in epithelial ovarian tumors,investigate their relationship with ovarian tumors in development aspect,determine different expression levels of ER and PR in different clinical stages,histological differentiation stages and pathological types,in order to lay the foundation for diagnosis,therapy of endocrines and genes in epithelial ovarian tumors.Methods:Pathological sections of ER and PR by immunohistochemical staining from 60 patients with epithelial ovarian tumors were detected.The analysis was performed on SPSS software,χ2 examination,exact probability means of four table.Results:①The positive rates of ER and PR in benign ovarian tumors(22 cases) were significantly lower than those in malignant ovarian tumors(38 cases)(P<0.01).②The positive rates of ER and PR in malignant ovarian tumors were different in different clinical stages.There was no significant difference between early(Ⅰ,Ⅱ) and late(Ⅲ,Ⅳ) period(P>0.05).③The expression of ER and PR in ovarian tumors in different histological differentiation stages was different.The positive rate of higher histological differentiation group was higher than that of lower histological differentiation group,showing no significant difference between each other.④The expression of ER and PR in ovarian tumors in different pathological types was different.In epithelial malignant ovarian tumors,the positive rate of serous fluid properties(21 cases) was significantly higher than that of mucus properties(15 cases)(P>0.05).Conclusion:①The positive rates of ER and PR in benign ovarian tumors and malignant ovarian tumors have significant difference.②The positive rates of ER and PR in malignant ovarian tumors are different in different clinical stages,histological differentiation stages and pathological types,showing no significant difference between each other.③Individual plans should be worked out to conduct therapy and judge prognosis.更多还原