【摘要】 目的:研究颅内出血早产儿血小板参数的变化,探讨其临床意义。方法:检测68例脑室周围-脑室内出血的早产儿血小板参数变化,并与同期无颅内出血的早产儿45例和正常足月新生儿27例的各项指标进行比较。结果:血小板计数分别为(292.96±46.91)×109/L、(220.61±35.01)×109/L和(188.85±51.62)×109/L,血小板压积分别为(0.232±0.07)%、(0.188±0.06)%和(0.126±0.04)%,提示脑室周围-脑室内出血患儿血小板计数和血小板压积显著降低(F=68.66,P<0.001);而血小板平均容积与血小板分布宽度差异不显著(P>0.05)。结论:血小板参数的异常变化可能参与了早产儿脑室周围-脑室内出血的发病机制,要重视对早产儿凝血状态的监测,以减少其发生。更多还原

【Abstract】 Objective:To study clinical significance of changes in parameters of platelet with periventricular intraventricular hemorrhages(PIVH)in premature infants.Methods:The parameters of platelet including platelet count(PLT,×109 L),thrombocytocrit(PCT,%),mean plate volume(MPV,fl)and platelet distribution width(PDW,%)were examined respectively in 68 premature infants with PIVH and 45 premature infants without PIVH and 27 healthy terminfants.Results:As compared with terminfants and premature infants without PIVH,PLT and PCT of infants with PIVH were lower singnificantly(PLT:292.96±46.91×109 L,220.61±35.01×109 L and 188.85±51.62×109 L,respectively PCT:0.232±0.07%,0.188±0.06% and 0.126±0.04%.F=68.66,P<0.001),while MPV and PDW were similarinall groups(P>0.05)。Conclusion:The changes inparameters of platelet may involve the pathogenesis of PIVH in premature infants,and more attention should be paid inmonitoring of coagulation status of premature infants so as to reduce the incidence of PIVH.更多还原