【摘要】 目的:评估术前24h联合应用甲氨喋呤(MTX)和米非司酮对异位妊娠腹腔镜保守手术的临床疗效。方法:随机选取2002年2月～2005年10月在我院行腹腔镜下异位妊娠保守手术的患者298例,根据术前检测血β-HCG是否大于3000U/L分为两组,比较其手术时间和术中出血量;在β-HCG≥3000U/L的患者中随机选取部分于术前24h分别联合应用MTX50mg单次肌内注射和米非司酮150mg口服(A组)和MTX50mg单次肌内注射(B组),并比较不同术前用药组和不用药组的手术时间和术中出血量。结果:术前血β-HCG≥3000U/L的异位妊娠患者行腹腔镜保守手术时其手术时间、术中出血量明显高于血β-HCG<3000U/L组,差异有显著性;A组的手术时间、术中出血量均小于B组和C组,差异亦有显著性。结论:对于绒毛活性强的异位妊娠患者在行腹腔镜保守手术前联合应用MTX和米非司酮有助于减少术中出血,缩短手术时间。更多还原

【Abstract】 Objective:To investigate the clinical value of MTX combined with Mifepristone for laparoscopic conservative operation in EP.Methods:From Feb.2002 to Oct.2005,342 EP patientswere treated by laparoscopy in Tongji Hospital.24 of them were prescribed MTX combined Mifepristone(group A)and 20 of them,only Mifepristone(group B),perceptively before operation.Results:The blood loss in laparoscopic conservative operation was higher when β-HCG ill blood was higher than 3000mlu/ml detected before operation.The operation time and blood loss of group A were spurious than that of group B and group C.Conclusion:MTX combined with Mifepristone used before laparoscopic conservative operation in EP is a valid method and appears to reduce the operation time and blood loss.更多还原