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甲氨喋呤联合米非司酮在异位妊娠腹腔镜保守手术中的应用

MTX combined with Mifepristone for Laparoscopic conservative operation in EP

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【作者】 刘丽江岳静何福仙

【Author】 LIU Li-Jiang,YUE Jing,HE Fu-Xian.Gynecological and Obstetrical Department,Tongji Hospital Affiliated to Tongji Medical College,Huazhong Science of Technology University,Wuhan 430030,Hubei,China

【机构】 华中科技大学同济医学院附属同济医院妇产科华中科技大学同济医学院附属同济医院妇产科 430030430030

【摘要】 目的:评估术前24h联合应用甲氨喋呤(MTX)和米非司酮对异位妊娠腹腔镜保守手术的临床疗效。方法:随机选取2002年2月~2005年10月在我院行腹腔镜下异位妊娠保守手术的患者298例,根据术前检测血β-HCG是否大于3000U/L分为两组,比较其手术时间和术中出血量;在β-HCG≥3000U/L的患者中随机选取部分于术前24h分别联合应用MTX50mg单次肌内注射和米非司酮150mg口服(A组)和MTX50mg单次肌内注射(B组),并比较不同术前用药组和不用药组的手术时间和术中出血量。结果:术前血β-HCG≥3000U/L的异位妊娠患者行腹腔镜保守手术时其手术时间、术中出血量明显高于血β-HCG<3000U/L组,差异有显著性;A组的手术时间、术中出血量均小于B组和C组,差异亦有显著性。结论:对于绒毛活性强的异位妊娠患者在行腹腔镜保守手术前联合应用MTX和米非司酮有助于减少术中出血,缩短手术时间。

【Abstract】 Objective:To investigate the clinical value of MTX combined with Mifepristone for laparoscopic conservative operation in EP.Methods:From Feb.2002 to Oct.2005,342 EP patientswere treated by laparoscopy in Tongji Hospital.24 of them were prescribed MTX combined Mifepristone(group A)and 20 of them,only Mifepristone(group B),perceptively before operation.Results:The blood loss in laparoscopic conservative operation was higher when β-HCG ill blood was higher than 3000mlu/ml detected before operation.The operation time and blood loss of group A were spurious than that of group B and group C.Conclusion:MTX combined with Mifepristone used before laparoscopic conservative operation in EP is a valid method and appears to reduce the operation time and blood loss.

  • 【文献出处】 中国妇幼保健 ,Maternal and Child Health Care of China , 编辑部邮箱 ,2008年02期
  • 【分类号】R713
  • 【被引频次】9
  • 【下载频次】68
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