【摘要】 目的:探讨流式细胞术检测宫颈细胞DNA倍体在宫颈病变中的应用价值。方法:对290例患者的液基细胞学检测后剩余细胞行流式细胞术DNA倍体分析,其中非典型鳞状上皮增生(ASCUS)120例、低度宫颈上皮内瘤变(LSIL)90例、高度宫颈上皮内瘤变(HSIL)60例、鳞状上皮癌(SCC)20例。结果:①异倍体在ASCUS组、LSIL组、HSIL组、SCC组中检出率分别为3.3%、31.1%、85.0%、96.7%。②LSIL、HSIL、SCC 3组的异倍体率与ASCUS组比较有显著性差异(P<0.05);HSIL、SCC 2组的异倍体率与LSIL组比较差异显著(P<0.05);HSIL、SCC 2组的异倍体率之间无统计学差异(P>0.05)。结论:DNA倍体分析可以作为宫颈病变早期的筛查手段。更多还原

【Abstract】 Objective:To explore the value of DNA ploid analysis by flow cytometry in cervical lesions.Methods:Flow cytometry(FCM) was used to detect the cervical cells of 290 patients(atypical squamous cells of undetermined significance(ASCUS)120,low-grade squamous intraepithelial lesion(LSIL) 90,high-grade squamous intraepithelial lesion(HSIL) 60,squamous cell cancer(SCC)20).Results:①The rate of heteroploid was 3.3% in ASCUS group,31.1% in LSIL group,85% in HSIL group,96.7% in SCC group.②Heteroploid level of LSIL,HSIL,SCC group differed from that of ASCUS group(P<0.05).Heteroploid level of HSIL,SCC group were different from that of LSIL group(P<0.05),while no significant difference was found between HSIL group and SCC group(P>0.05).Conclusion:DNA content analysis is helpful in early diagnosis of the cervical lesions.更多还原