【摘要】 目的:以那如三味丸为研究对象,考察荜茇、诃子对草乌药效组分的影响规律。方法:利用电喷雾质谱技术分别对那如三味丸,草乌加诃子、荜茇共煎液进行系统考察。结果:乌头碱加诃子共煎液中乌头碱含量高;草乌加诃子共煎液中乌头碱含量较低;荜茇对草乌生物碱的影响不明显。结论:诃子对制草乌起减毒作用,其减毒机制主要是抑制了制草乌中乌头碱的溶出。更多还原

【Abstract】 AIM:To study the bioactive components effect of every kind of herbal in Naru Sanwei Pill (Fructus litseae, Fructus chebulae) on Radix Aconiti kusnezoffii. METHODS: Analysising the Naru Sanwei Pill, adding the extraction of Radix Aconiti kusnezoffii to Fructus chebulae and Fructus litseae and was analyzed by ESI-MS~n. RESULTS: The quantity of mesaconitin was low in the extraction of Aconitum kusnezoffii Reichb,and Fructus chebulae.Long Pepper did not have much effect on alkaloids of Aconiti kusnezoffii Reichb. CONCLUSION: Fructus chebulae reduced toxicity in the process of Radix aconiti kusnezoffii,through lowering the dissolving-out of aconitine.更多还原