【摘要】 目的:探讨清胃散(生地、当归、丹皮、黄连等)清胃热的作用机理。方法:5%乙醇代水供小鼠自由饮用并用附子、干姜、肉桂提取物灌胃造模。部分模型鼠同时给予清胃散。3周后观察小鼠肛温、炭末排出时间、胃组织中cAMP、SOD、MDA含量及胃和舌的组织学变化。结果:清胃散治疗对胃热证模型组的生化和组织学变化等均有所改善。结论:本方法建立胃热证的病理模型符合中医理论;清胃散对实验动物具有清胃热的作用。更多还原

【Abstract】 AIM:To investigate the principle of function of Stomach-Clearing Powder (Radix Rehmanniae, Radix Angelicae Sinensis, Cortex Moutan Rhizoma Coptidis, etc.) on clearing the stomach-heat. METHODS: 5% alcohol water were used as drink water of mice to make model. In the treatment group, "Stomach-Clearing Powder" was administed. Three weeks later, the anal temperature, the evacuation time of active carbon powder,stomach cAMP, SOD, MDA and the pathological changes in stomach and tongue were observed and recorded. RESULTS: "Stomach-Clearing Powder" could can obviously improve the pathological changes of the model group with stomach-heat syndrom. CONCLUSION: The established pathological model of stomach-heat syndrome accorded with traditional Chinese medicine; "Stomach-Clearing Powder" has the effect on clearing the stomach-heat on the experimental mouse.更多还原