【摘要】 目的:研究了野菊花滴丸(野菊花)制备的影响因素,确立了最佳制备工艺条件。方法:以丸重差异、综合质量和溶散时限为评价指标,采用正交设计试验对各影响因素进行考察。结果:以聚乙二醇6000:聚乙二醇400=54∶6为基质,二甲基硅油为冷凝剂,滴头口径(内-外径)为6.2~9.0 mm,药物与基质比例为1∶3,药液温度为70℃、滴速为30 d/min。制得的滴丸丸重差异小、综合质量好、溶散时限短,与颗粒剂比较更便于服用,吸湿性小。结论:该滴丸质量稳定,重现性好,设备简单,适于工业化生产。更多还原

【Abstract】 AIM:To optimize the technical parameters indica-daisy dropping pill(Flos chrysanthemi indici) through controlling the influencing factors. METHODS:To take weight variation of pills,comprehensive quality and disintegration time limited as index,the above factors were observed by orthogonal test. RESULTS:Good technological parameters of indica-daisy dropping pill were as follows PEG6000∶PEG400=54∶6 as matrix,dimethicone as refrigerant.Temperature of drug fluids of 70 ℃,internal and external diameter of dropper within 6.2 mm and 9.0 mm,proportion of drug and matrix(1∶3),30 dropping per minute.The weight variation of pills was small,type quality was good and disintegration time limited was short.The water absorbability was smaller than that of granules. CONCLUSION:The finished products are of good quality and appropriate for mass production.更多还原