【摘要】 目的研究雄激素相关基因CYP11α基因多态性与云南汉族痤疮发病危险性的关系,从分子遗传学角度探讨痤疮的发病机制。方法对206例云南汉族痤疮患者和200例健康对照者外周血的DNA样本采用PCR-genescan法检测CYP11α基因的tttta微卫星多态性位点,同时对两组患者的多态性位点基因型分布频率进行比较。结果男性重型痤疮中215-和215+基因型频率(59%,41%),与男性对照组(40.1%,59.1%)相比差异有显著性(P<0.05),但在女性痤疮组以及男性轻型痤疮组中这两种基因型频率分布与各自对照组相比未发现差异(P>0.05)。结论CYP11α基因的tttta微卫星重复多态性与云南汉族男性重型痤疮相关,CYP11α基因215-基因型可能是男性重型痤疮的遗传易感因素之一。更多还原

【Abstract】 Objective To investigate the relationship between the CYP11α gene polymorphism and acne in Han population of Yunnan province.Methods Genescan-PCR techniques were used to detect the tttta polymorphism of CYP11α gene from the peripheral blood samples of 206 patients with acne and 200 normal control in Han nationality of Yunnan province.The distribution frequencies of polymorphism were compared between patients group and controls.Results The frequencies of 215-and 215+ genotype were 59% and 41% in the male severe acne.Comparing with the male controls(40.1%,59.1%),the difference was statistically significant(P<0.05),but we also didn’t find difference in the female patients and moderate male patients comparing with respectively controls.Conclusion CYP11α genes are associated with severe male acne in the Han nationality of Yunnan province.更多还原