【摘要】 目的:对我院住院患者的β-内酰胺类抗生素使用情况、病例病原学检查及药敏试验进行调查分析,为临床合理使用抗菌药物提供依据。方法:对2006年1月~2007年6月β-内酰胺类抗生素的总消耗金额、用药频度(DDDs)、日治疗费用和病原菌耐药性进行统计、分析。结果:调查期内β-内酰胺类抗生素的总用药频度增长26.07%;药物的DDDs排序前4位大多数为限制使用的二线抗菌药物;大多数抗生素在调查期内细菌耐药率的差别不显著。对革兰阳性球菌耐药率最低者为阿莫西林/克拉维酸,其次为头孢克洛、亚胺培南;对革兰阴性杆菌耐药率最低者为美罗培南,其次为亚胺培南、哌拉西林/他唑巴坦及头孢吡肟。结论:β-内酰胺类抗生素的使用情况有较明显的改善,部分细菌耐药性有所改善,但仍有部分药物用量呈上升状态,表明仍存在不合理使用现象。更多还原

【Abstract】 OBJECTIVE: To probe into the utilization of β-lactam Antibiotics in the inpatients in our hospital,the etiological test and drug susceptibility test so as to provide basis for the rational use of antibiotics.METHODS: The total consumption sum,DDDs,DDC and bacterial drug resistance of β-lactam antibiotics from Jan.2006 to June 2007 were analyzed statistically.RESULTS: The DDD of β-lactam antibiotics witnessed an increase of 26.07% from Jan.2006 to June 2007. Most of the top 4 drugs on the list of DDDs were second line antibiotics which had a limited use.The differences for most of the β-lactam antibiotics in bacterial drug resistance were non-significant.Amoxil/ clavulanic acid showed the least resistance to G+ cocci,followed by cefaclor and imipenem.Meropenem showed the least resistance to G-bacillus,followed by imipenem,piperacillin/ tazobactam and cefepime.CONCLUSION: The utilization of β-lactam Antibiotics has an marked improvement,and the bacterial drug resistance of some bacteria improved as well.However,the uptrend consumption of some drugs is suggestive of the existence of non-irrational drug use.更多还原