【摘要】 目的评价三维适形放疗联合多西紫杉醇与卡铂治疗食管癌的疗效及不良反应。方法不能手术治疗的食管癌患者39例行多西紫杉醇联合卡铂方案化疗,28天为1周期,共4个周期;三维适形放射治疗在化疗第1天同期进行,总放射剂量为60~70 Gy/6~7周。结果39例患者同期放化疗毒性可耐受,总有效率(CR+PR)97.4%。3年中位生存时间为22.5月,1、2、3年生存率分别为82.1%、67.7%、43.1%。1、2、3年局部控制率分别为79.5%、71.8%、59.0%。结论三维适形放疗联合多西紫杉醇与卡铂治疗食管癌的疗效较好,毒副反应患者能耐受。更多还原

【Abstract】 Objective To evaluate the efficacy and adverse effects of the three dimensional conformal radiation therapy(3D-CRT) concurrently combined with chemotherapy of docetaxel and carboplatin for inoperable esophageal cancer.Methods 39 patients with inoperable esophageal cancer received 4 cycles of docetaxel and carboplatin chemotherapy and 4 weeks was a cycle.At the same time,3D-CRT was given along with the first cycle chemotherapy,and the total radiation dose was 60~70Gy/6~7 weeks.Results The toxicity was tolerable in 39 patients received 3D-CRT concurrently combined with chemotherapy.The total effective rate was 97.4%.The median living time was 22.5 months,and the 1、 2、 3-year survival rates and the local control response rates were 82.1%,67.7%,43.1% and 79.5 %,71.8%,59.0% respectively during three year follow-up visit.Conclusion The 3D-CRT concurrently combined with chemotherapy for patients with inoperable esophageal cancer is more effective,and the patients could tolerate the side effects.更多还原