【摘要】 目的探讨维持性血液透析(MHD)患者C反应蛋白(sCRP)与血清营养指标、血脂及心功能的关系。方法测定76例MHD患者和44例健康对照者血清sCRP、血红蛋白(HGB)、血清前白蛋白(PRE)、血清白蛋白(ALB)、转铁蛋白饱和度(TSAT)、血清胆固醇(CHOL)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL);应用超声心动图测定左室舒张末内径(LVEDD)、室间隔厚度(IVS)、射血分数(EF),并与sCRP进行相关性分析。结果MHD患者sCRP水平显著高于健康对照组;sCRP与血清营养指标HGB、PRE、ALB、TSAT有负相关性,与CHOL有相关性,均P<0.05;与TG、HDL、LDL及心功能指标LVEDD、IVS、EF无相关性。结论sCRP是反映MHD患者炎症及营养状态的一项敏感指标,与血脂关系不肯定,不能作为预示心功能的指标。更多还原

【Abstract】 Objective To investigate the relationship between serum C-reactive protein(sCRP)and serum nutrition indices,plasma lipids,and markers of cardiac function.Methods The serum CRP levels were measured in 76 patients with maintenance hemodialysis(MHD)and 44 healthy controls.Nutrition indices(HGB,PRE,ALB,TSAT)and lipids(CHOL,TG,HDL,LDL)were detected in MHD patients and controls.The left ventricular end-diastolic dimension(LVEDD),interventricular septal thickness(IVST),ejection fraction(EF)were detected by echocardiography.The correlative analysis among serum CRP levels and nutrition indices,plasma lipids,markers of cardiac function was assessed.Results Serum CRP levels in MHD patients were significantly higher than those in health controls(P < 0.05).Serum CRP levels in MHD patients were negatively correlated with HGB,HGB,PRE,ALB,TSAT and were not correlated with plasma lipids and LVEDD,IVS,EF.Conclusion Serum CRP levels may predict the nutritional state of MHD patients.There is uncertainly relationship between serum sCRP levels and plasma lipids and thus serum CRP cannot predict cardiac function of MHD patients.更多还原