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通脉胶囊对大鼠实验性脑缺血的保护作用

Protective Effects of Tongmai Capsule on Experimental Cerebral Ischemic Injury in Rats

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【作者】 王淑君王风霞张国伟

【Author】 Wang Shujun1,Wang Fengxia2,Zhang Guowei3 (1.Department of Pharmary,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China 450052; 2.Pharmacy Centre of Henan Province,Zhengzhou,Henan,China 450004;3.The First Hospital of Quanzhou City,Quanzhou,Fujian,China 362000)

【机构】 郑州大学第一附属医院药剂科河南省药品审评认证中心福建省泉州市第一人民医院

【摘要】 目的研究通脉胶囊对大鼠实验性脑缺血的保护作用。方法采用结扎大鼠大脑双侧总动脉形成急性实验性不完全性脑缺血模型,观察通脉胶囊对脑含水量、毛细血管通透性、脑组织损伤等方面的影响。结果通脉胶囊可明显降低脑含水量、毛细血管通透性,减轻脑组织损伤。结论通脉胶囊对大鼠实验性脑缺血有显著的保护作用。

【Abstract】 Objective To study the protective effects of Tongmai Capsule on the experimental cerebral ischemic injury in rats.Methods The rat experimental model of cerebral ischemic injury was established by bilateral cerebral artery ligature.The effects of Tongmai Capsule on water contents of brain,capillary permeability and injury of brain tissue were investigated.Results In rat model of cerebral ischemic injury,2.0,4.0,6.0 g/kg of Tongmai Capsule markedly decreased water content of brain and capillary permeability,and significantly reduced injury of brain tissue.Conclusion Tongmai Capsule has the protective effects on cerebral ischemic injury in rats.

【关键词】 通脉胶囊脑缺血保护作用
【Key words】 Tongmai Capsulecerebral ischemicprotective effect
  • 【文献出处】 中国药业 ,China Pharmaceuticals , 编辑部邮箱 ,2008年14期
  • 【分类号】R285.5
  • 【下载频次】36
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