【摘要】 目的:探讨同期放化疗治疗中晚期鼻咽癌(Ⅲ或Ⅳa期)的疗效。方法:回顾分析116例中晚期鼻咽癌的随访资料,根据治疗方法不同分为同期放化疗联合组(A组)和单纯放疗组(B组)。结果:同期放化疗联合组在肿瘤的消失方面明显高于单纯放疗组,两者差异有统计学意义(P<0.05)。放化疗联合组1、3、5年的生存率明显高于单纯放疗组,两者差异均有统计学意义(P<0.05);化疗最常见的不良反应为骨髓抑制和消化道反应,无Ⅲ度以上的不良反应和化疗相关死亡。放疗的不良反应主要为轻度骨髓抑制和口腔黏膜及皮肤反应,但无中途停止和放疗相关死亡。结论:同期放化疗治疗中晚期(Ⅲ或Ⅳa期)鼻咽癌是目前较为理想的治疗方案。更多还原

【Abstract】 Objective:To explore the effect of radiotherapy combined with concurrent chemotherapy for the treatment of advanced nasopharyngeal carcinoma(stage Ⅲ and Ⅳa).Methods:Data of 116 advanced nasopharyngeal carcinoma patients were analyzed retrospectively.The patients were divided into two groups based on different treatment methods.Group A received radiotherapy with concurrent chemotherapy,while group B received radiotherapy only.Results:The complete response rates of primary tumor in group A were more effective than those in group B(P<0.05).One,three and five-year survival rates of group A were significant higher than those of group B respectively(P<0.05).The most common toxicities were digestive tract effect and neutropenia.There were no grade 4 clinical toxicity and treatment-related death in the series.Systemic adverse effects frequently occurred during radiotherapy were esophagitis,Oral mucosa and cutaneous reaction,which were tolerable.Conclusion:Radiotherapy with concurrent chemotherapy is currently an effective method in the treatment of advanced nasopharyngeal carcinoma(stage Ⅲ and Ⅳa).更多还原