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HPLC法测定复方感冒灵中马来酸氯苯那敏的含量
Content determination of chlorpheniramine by HPLC
【摘要】 目的:建立马来酸氯苯那敏含量测定的方法。方法:用HPLC法测定马来酸氯苯那敏的含量,用C18柱以乙腈-水(75∶25)为流动相进行含量测定。结果:马来酸氯苯那敏在0.00808~0.40400mg/ml范围内呈良好的线性关系(r=1.0000)。结论:该方法准确、灵敏、重现性好,可以用该方法来检测马来酸氯苯那敏的限度,控制其成品的质量。
【Abstract】 Objective:To establish the content determination method for chlorpheniramine by HPLC.Methods:The C18 column was used,the mobile phase was acetonitrile-water(75∶25) .Results:There was a good linearity in the range of 0.008 08 ~0.404 00 mg/ml(r=1.000 0) .Conclusion:This method is acurate,sensitive and has good reproducibility.It can be used for the quality control of the product.
- 【文献出处】 中国医药导报 ,China Medical Herald , 编辑部邮箱 ,2008年15期
- 【分类号】R927
- 【被引频次】4
- 【下载频次】136