【摘要】 目的:了解不稳定型心绞痛(UAP)患者冠脉循环中血小板计数(PC)和纤维蛋白原(Fg)的变化。方法:选20例UAP患者和10例经冠脉造影证实冠状动脉无狭窄的正常人,在做冠脉造影时,同时采集冠状静脉窦(CS)、主动脉根部(AO)和上腔静脉(SVC)血,测定血小板计数(PC)及纤维蛋白原(Fg)浓度。结果:与正常人相比,UAP患者CS中Fg浓度增高(P<0.01),PC无显著差异(P>0.1)。在心绞痛发作当时采血的3例UAP患者,其CS中血小板计数(PC)及纤维蛋白原(Fg)比周围循环中低。结论:纤维蛋白原(Fg)增高是冠心病发病的危险因素。在心绞痛发作时,冠状动脉内存在血小板聚集、血栓、微血栓形成。更多还原

【Abstract】 Objective:To assess the changes of fibrinolysis(Fg) and platelet counts(PC) in coronary circulation of unstable angina pectoris(UAP). Methods:20 UAP patients and 10 control subjects with arteriographically normal coronary arteries were collected simulteaneously from coronary sinus(CS),aortic root(AO),and superior vena cava(SVC)while coronary arteriography performed.Plasma Fg and PC were analyzed.Results:The plasma concentration of Fg were higher than that of control subjects(P<0.01),platelet counts had no difference.The PC and concentration of Fg in CS of UAP patients who were having angina pectoris while samples with drawn were lower.Conclusion:The increase in Fg is the risk factor of coronary heart disease. There is an increased platelet aggregation and thrombus or mircrothrobus formation.更多还原