【摘要】 尿酸是嘌呤代谢的终产物。研究尿酸在胰岛素抵抗为主2型糖尿病、高血压及动脉粥样硬化、冠状动脉粥样硬化性心脏病(冠心病)及脑血管病变的发生发展过程中所起的作用,一直以来都是世界各国学者研究的热点。目前研究认为高尿酸血症和低尿酸血症在胰岛素抵抗为主2型糖尿病患者中是两种不同的存在形式,而体外试验及动物实验研究发现尿酸有促进炎症作用,可致血管内皮细胞功能紊乱,从而影响大血管病变的发生,发展。更多还原

【Abstract】 Uric acid is a final product of metabolic block of purin metabolism.It is a hot topic in the whole-world to study the effect of uric acid on the type-2 diabetes with insulin resistin,hypertension,atheroslerosis,cornonary heart disease,as well as cerebral vascular disease.At present,some research results show that hyperuricemia or hypouricemia can be observed in the type-2 diabetes.The investigation of outbody examination and animal examination find that uric acid will accelerate inflammatory to endothelial dysfunction,which can result in the occurrence and development of Macrovascular Complications.更多还原