【摘要】 死亡相关蛋白激酶(DAPK)是一种凋亡的正性调节因子,可促进肿瘤细胞的分化并抑制肿瘤的转移,被认为是肿瘤的抑制剂。DAPK基因启动子超甲基化或蛋白表达异常在多种肿瘤中均可观察到,并与分级分期及预后呈一定相关,表明其在肿瘤的发生及进展中发挥一定作用,在肿瘤的早期诊断、评价预后及基因靶向治疗等方面有重要意义。现就DAPK与肿瘤的诊断与治疗的研究进展予以一综述。更多还原

【Abstract】 Death associated protein kinase is a positive regula tory factor of apo ptosis,known as an inhibitor of tumor,which may promote the differentiation an d inhibit the metastasis of tumor cells.The hypermethylated of gene promoter or abnormal expression of DAPK has been demonstrated in a variety of tumors,which has been demonstrated to be associated with grade,stage or prognosis of tumor.Therefore,DAPK may play important roles in the development and progression of tumor,and should have important significance in early diagnosis,evaluation of prognosis or gene target therapy.This article reviewed the progresses in DAPK a nd diagnosis and therapy of tumor.更多还原