【摘要】 目的探讨血清IL-18、IL-18BP的水平与原发性肝癌发生、发展的关系。方法应用ELISA法检测28例原发性肝癌患者、21例肝硬化患者及18例正常人血清IL-18及IL-18BP的含量,比较它们之间的关系。结果原发性肝癌患者血清IL-18水平明显低于正常人和肝硬化患者,IL-18BP的水平明显高于正常人和肝硬化患者(P<0.05);肝硬化患者血清IL-18及IL-18BP水平均明显高于正常人(P<0.01)。结论外周血IL-18及IL-18BP水平可作为反映原发性肝癌患者及肝硬化患者的免疫功能状态指标,也可以作为原发性肝癌的诊断指标。更多还原

【Abstract】 Objective To study the relationships between serum IL-18 and IL-18BP and the development,metastasis,curative effect and prognosis of primary liver cancer.Methods There were total 49 cases patients,of which 28 cases primary hepaticcarcinoma(PHC)and 21 cases liver cirrhosis(LC),and 18 cases heathy people.Their serum levels of IL-18 and IL-18BP were determined by using an ELISA assay and comparation.Results The serum IL-18 in PHC was significantly lower than that in LC and controls;the serum IL-18BP in PHC was significantly higher than that in LC and controls;the IL-18 and IL-18BP in LC were significantly higher than those in controls(P<0.05 or 0.01).Conclusion Serum levels of IL-18 and IL-18BP can be target of relating to immune functions of PHC patients and LC patients,and can be target of diagnosing primary liver cancer.更多还原