【摘要】 目的探讨血清CA199、CA125水平和肝硬化、肝癌的关系。方法应用化学发光免疫分析对56例肝硬化和32例肝癌患者进行了血清CA199、CA125水平检测并50名正常健康人作对照。结果肝硬化Child分级各组、肝癌组CA199分别为:32.7±23.5n/ml、72.1±58.4n/ml、107.3±76.5n/ml、118.5±72.4n/ml(P<0.01),以<35U/m为界限值,肝硬化组阳性率为53.57%、肝癌组阳性率为78.1%,均显著地高于正常人组(P<0.01),肝硬化Child分级各组间、肝硬化组与肝癌组CA199水平及阳性率亦有显著差异(P<0.05)。CA125水平及阳性率在肝硬化、肝癌组均显著高于正常人组(P<0.01),随肝功能下降,CA125水平明显增高(P<0.05)。结论CA199、CA125水平可作为肝硬化与肝癌的辅助诊断指标,对于判定肝功能有很大意义。更多还原

【Abstract】 Objective To study of the relationship of serum CA199 and CA125 levels between hepatocirrhosis and carcinoma of liver.Methods Serum CA199 and CA125 levels in 56 patients with cirrhosis, 32 patients with carcinoma of liver and 50 controls were determined with chemoluminescence immunization analysis method. Results Serum CA199 levels were 32.7±23.5 n/ml、72.1±58.4 n/ml、107.3±76.5 n/ml、118.5±72.4 n/ml(P<0.01) in patients with in patients with cirrhosis of liver Child grade A.B.C and carcinoma of liver, respectively. Taking 35U/ml as the upper normal limit, the positive rate was 53.57%、78.1%, respectively. The values were significantly higher than those in the controls(P<0.01). Difference between the values of the two patient groups was also significant(P<0.05). Serum CA125 level and positive rate in patients with cirrhosis of liver and carcinoma of liver were significantly higher than those in the controls(P<0.01). Along with the degradation of liver function , Serum CA125 level were significantly higher(P<0.01). Conclusion CA199 and CA125 could be used as necessary parameters for diagnosis of cirrhosis and carcinoma of liver, and have significant value of determine the liver function.更多还原