【摘要】 目的探讨脂联素单核苷酸多态性SNP45T→G和SNP276G→T与原发性高血压之间的关系。方法原发性高血压病患者80例,正常对照160例,以聚合酶链式反应-限制性内切酶长度多态性(PCR-RFLP)技术,对脂联素基因SNP45、SNP276多态性位点进行基因分型。结果SNP45和SNP276两个多态性位点的基因型和等位基因频率在原发性高血压和正常对照组中的分布无显著差异(>0.05)。结论脂联素基因SNP45和276多态性可能不是武汉地区汉族人群中原发性高血压发病的遗传学标志。更多还原

【Abstract】 Objective To explore the association betweem adiponectin gene variants (SNP45T→G and SNP276G→T) and essential hypertension. Methods 80 hypertensive patients were genotyped for single-nucleotide polymorphisms(SNPs)45T→G and 276G→T. Results No association of single nucleotide polymorphism 45 or single nucleotide polymorphism 276 with hypertension was found. Conclusion The T45G and G276T of the adiponectin gene may not be an important determinant of hypertension in Chinese subjects.更多还原