肺癌和结核性胸腔积液/血清RANTES的测定及意义

【摘要】 目的研究肺结核以及肺癌所致的胸水中趋化因子(调节活化正常T细胞表达)和分泌因子(RANTES)的表达水平及临床意义。方法用酶联免疫吸附法(ELISA)测定22例肺结核,15例肺癌患者以及正常对照20例血清和/或胸水中RANTES的水平。结果肺癌患者血清及胸水中RANTES水平升高较肺结核患者升高明显。结论趋化因子在结核和肿瘤中发挥不同的T细胞免疫应答,为以后的应用奠定实验基础。更多还原

【Abstract】 Objective The expression of regulated on activation normal T cell expressed and secreted(RANTES),in patients with tuberculous and lung cancer were analyzed.So that to fi nd out the role of RANTES in the pathophysiologieal process of tuberculous and malignant effusion.Methods The concentration of RANTESin serum and pleural effusions samples from 22 tuberculous and 15 patients were determined by enzyme-labeled immunerbent assay(ELISA) and were compared with healthy donors.Results The expression of RANTES was signifi cantly higher in lung cancer patients than that in tuberculous pleural effusions.Conclusion RANTES play a different role of T cell’s immune response in tuberculous and malignant pleural effusions.更多还原