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体外条件对不同类型灯盏花素缓控释制剂释放行为的影响

Effects of in vitro conditions on release behavior of different types of sustained and controlled release formulations of breviscapin

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【作者】 何燕曾祥腾潘卫三

【Author】 HE Yan~(1,2),ZENG Xiang-teng~2,PAN Wei-san~1(1.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China;2.Sustained-and Controlled-released Preparation Center of Guangzhou Pharmaceutical Industry Research Institute,Guangzhou 510240,China)

【机构】 沈阳药科大学药学院广州市医药工业研究所缓控释制剂中心

【Abstract】 Insoluble breviscapin was chosen as the model drug.Bi-layer osmotic pump technology and gel matrix technology were used to prepare the breviscapin sustained and controlled release preparations.Dissimilarity factors(f1) and similarity factors(f2) were applied as similar judgment index to compare the effects of in vitro conditions on the release behavior of different types of breviscapin sustained and controlled release preparations.The tolerance of in vitro release conditions of bi-layer osmotic pump technology and gel matrix technology were studied.The results showed that in vitro release conditions have a greater impact on the gel matrix sustained release formulations,while have almost no effects on the osmotic pump controlled release formulations.Therefore,osmotic pump controlled release technology is less affected by the drug release environment.And it has a very good application prospect.

  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,2008年11期
  • 【分类号】R283
  • 【被引频次】3
  • 【下载频次】193
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