【摘要】 目的:观察脉宽调制音频信号对高血压模型大鼠血压的影响。方法:分别取带通频率为100Hz、350Hz、1000Hz、3500Hz和20Hz～20000Hz(以下称全音频)的音频信号经脉宽调制后对继发性高血压模型大鼠"足三里"穴位进行电刺激,观察其对即时血压的影响。结果:比较实验前后收缩压及心率的变化,从带通频率为350Hz和全音频取出的信号均能降低模型大鼠收缩压(P<0.05),且两组降压效果相似(P>0.05);100Hz组、350Hz组和全音频组三组均有减慢心率作用(P<0.05),100Hz组和350Hz组减慢心率的效果相似(P>0.05),并发现全音频组减慢心率的作用强于100Hz组和350Hz组;1000Hz组模型大鼠收缩压升高(P<0.05)。结论:在某些特定的带通频率范围内所取出的音频信号经调制后作用于双肾双夹肾动脉狭窄高血压模型大鼠,能即时降低收缩压,同时减慢心率。也提示了不同带通频率的音频脉冲信号对于继发性高血压模型大鼠血压有双向调节作用。更多还原

【Abstract】 Objective: The effect of Pulse width modulation audio signals of Zusanli(ST 36)on the blood pressure in Hypertension model rats was observed. Methods: We treated the Secondary Hypertension model rats with pulse width modulation audio signals with band-pass frequency of 100 Hz,350 Hz,1000 Hz,3500 Hz and 20 Hz～20000 Hz(full audio frequency), respectively,and observed the signals’ effect on the rats’ current blood pressure. Under the same condition, we measured rats’ blood pressure and heart rate before and after the treatment. Results: The signals picked up from 350 Hz and full audio frequency decreased the rats’ systolic blood pressure (P<0.05), nor did the others. In groups of 100 Hz,350 Hz and full audio frequency, heart rate was showed(P<0.05):groups of 100Hz and 350 Hz have similar effects, and group of full audio frequency have a stronger effect.Treated with the signal picked up from 1000 Hz band-pass frequency, the rats’ SBP increased (P<0.05). Conclusion: Experiments indicate that modulated audio signals, which is picked up from some special band-pass frequency, can instantaneously decrease the SBP and heart rate of two-kidney, two clip renovascular hypertensive rats. It also displays that audio pulse signals with diff erent band-pass frequency have a two-way function in regulating the Secondary Hypertension model rats’ blood pressure.更多还原