【摘要】 聚乙二醇(PEG)修饰在改善蛋白质类药物的理化性质的同时也会导致其体内药代动力学行为发生变化。而PEG修饰剂的分子大小、分子结构和修饰位点对蛋白质类药物的体内药代动力学行为和活性具有一定影响。根据有关文献报道,讨论这些影响因素,并介绍在对PEG修饰药物进行药代动力学研究时采用的新方法,如:群体药代动力学预测法及体内测定修饰物含量的电化学发光法和PEG特异性抗体法等。更多还原

【Abstract】 PEG-modification was assumed to be one of the optimal approaches improving the physical and chemical characteristics and changing pharmacokinetic properties of protein in biological medication field.The influences of PEG molecular size,molecular structure and modification site on the PEG-protein pharmacokinetic properties and biological activity in vivo have been reviewed according to the references.Some related pharmacokinetic research methods,such as population pharmacokinetics,and electro-chemical luminescence(ECL) and PEG specific antibody method which are used to determine PEG-protein in vivo were also introduced.更多还原