【摘要】 目的探索血小板活化异常与糖尿病肾病(DN)的关系。方法我们采用流式细胞术检测116例2型糖尿病(DM)患者周围血中CD+62p,CD+63,CD+31,CD+41及血浆α-颗粒膜蛋白(GMP140)含量测定(ELISA法),并依据24h尿白蛋白排出率(UAER)将其分为正常白蛋白尿组(DM1)、微量白蛋白尿组(DM2)、大量白蛋白尿组(DM3),并与40例正常人对照(NC)。结果周围血中CD+62p,CD+63,CD+31,CD+41及血浆GMP140在DM各组均较NC组升高,特别是DM2,DM3组较NC组明显升高。DM合并高血压者周围血中CD+62p,CD+63,CD+31,CD+41及血浆GMP140均较无高血压者为高(P<0.05)。结论血小板活化的增强可能与DN的发生、发展相关。更多还原

【Abstract】 Objective To explore the relationship between platelet activation abnormality and diabetic nephropathy(DN) in type 2 diabetes mellitus (DM)patients. Methods 116 type 2 diabetes mellitus patients were measured of the levels of CD+62p,CD+63,CD+31,CD+41 and GMP140(one of quota reflecting platelet activation)by flow cytometer. These patients were divided into three groups according to UAER levels:DM1(UAER<20μg/min), DM2(UAER 20~200μg/min)and DM3(UAER>200μg/min),and compared with 40 normal individuals(NC). Results CD+62p,CD+63,CD+31,CD+41 and GMP140 in each patient group were higher than NC,especially those in DM2 and DM3 were significantly higher than NC. CD+62p,CD+63,CD+31,CD+41 and GMP140 in DM patients with hypertension were higher than those without hypertension(P<0.05). Conclusion The enhancement of platelet activation may be correlated with DN.更多还原