【摘要】 eIF3是相对分子质量最大和最复杂的一个真核细胞翻译起始因子,它在真核细胞翻译调控中发挥非常重要的作用。最近研究发现,eIF3的许多亚基在人类肿瘤中表达量发生改变,从而影响肿瘤的发生、发展和预后。本文主要对eIF3亚家族与肿瘤发生的关系进行综述。更多还原

【Abstract】 eIF3 is the largest and most complex eukaryotic initiation factor in mammals,and it plays an important role in the regulation of translation.Some studies showed that the changes of levels of gene and protein expression of many subunits in eIF3 family are associated with the development,progression,and prognosis of human tumors.The relationship between eIF3 subfamily and the tumor development and progression was reviewed in this article.更多还原