【摘要】 目的探讨铜绿假单胞菌临床分离株的感染分布情况及其对14种抗生素体外耐药性,指导临床合理应用抗生素。方法采用K-B纸片扩散法对2004年1月～2005年12月年住院患者分离的铜绿假单胞菌进行抗生素敏感性测定,同时对其感染分布及耐药性进行分析。结果两年内共检出182株铜绿假单胞菌。感染部位依次为:呼吸道(82.4%)、伤口(12%)和泌尿道(3.8%)等。铜绿假单胞菌对14种抗生素敏感性较高的是亚胺培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦,分别为3.2%、7.1%、9.8%,耐药率较高的是头孢噻肟、头孢唑啉,耐药率为47.8%、39%。结论本院铜绿假单胞菌分布以呼吸道为主,对碳青酶烯类、β-内酰胺酶抑制剂复合物保持较好的敏感性,但耐药情况有随时间增加的趋势,头孢三代的耐药率高于国家细菌耐药监测研究组(BRSSG)的结果,所以应加强对铜绿假单胞菌耐药性的监测,合理应用抗生素是延缓耐药菌株增加的最有效办法。更多还原

【Abstract】 Objective To investigate the distribution of pseudomonas aeruginosa in the hospital infection and its antibioticy to 14 kinds of antibiotics. Guiding the clinical reasonable uses of the medicine Methods K-B method was useed to determine the resistance of 182 strains of pseudomonas aeruginosa isolated and cultured from clinical samples in 2004~2005. Result 182 pseudomonas aeruginosaes were isolated .82.4% were from breath way ;12% and 3.8% were from wound and urine respectively.The rates of resistance to antibiotic were Imipenem 3.2%,Piperacilin/tazobactan7.1%,Cefoperazone/sulbactam9.8%,Cefotaxime47.8%,cefazolin39% Conclusion pseudomonas aeruginosa showed good sensitivity to Carbapenems and β-lactam antibiotics ,but resistance to third-generaion cephalosporins was higher in our hospital than whole nation in 2003.It is very important to select antibiotic correctly according to the results of susceptibility tests.更多还原