【摘要】 目的探讨腹膜透析(PD)对急性出血坏死性胰腺炎(AHNP)的疗效及机制。方法24例AHNP患者,在接受常规综合治疗的同时,行间歇性腹膜透析(IPD)治疗。PD治疗前后监测病情及生化指标的变化,并测定血中细胞因子和炎症介质水平。结果PD治疗后患者心动过速,呼吸窘迫、腹痛、腹胀等症状明显缓解;总胆红素(TB)、淀粉酶(AMS)、脂肪酶(LPS)、尿素氮(BUN)、肌酐(Cr)明显降低;血肿瘤坏死因子a(TNF-a)、白细胞介素-1β(IL-1β)、C-反应蛋白(CRP)和内毒素水平明显下降;24例患者中19例治愈,5例死亡,死亡率为20.8%。结论PD治疗能降低AHNP并发MODF的病死率,提高抢救的成功率。更多还原

【Abstract】 Objective o explore the efficacy and mechcanism of the peritoneal dialysis(PD) in treatment of acute hemorrhagic necrotic pancreatitis (AHNP). Motheds 24 AHNP Patients was treated with conventional theraphy companied by intermittent peritoneal dialysis (IPD). During PD ,the patients conditions and markers of biochemistry were observed , and the serum concentrations of cytokine and inflammatory factor were measured . Results After PD, the patients symptoms such as tachycardia, respiratory distress, abdominal pain were remission. The serum levels of total bilinogen(TB), amylase(AMS),lipopolyse(LPS),tumor necrosis factor-a(TNF-a),interleukin-1β(IL-1β), C-reactive protein (CRP) and endotoxin were decreased singnificantly. Five patients died .The mortality rate was 20.8%. Conclusion PD Can decrease mortality rate of AHNP with MODF.更多还原