【摘要】 黄素单加氧酶(FMO,E.C.1.14.13.8)是重要的Ⅰ相代谢酶,由于与细胞色素P450(CYP450,E.C.1.14.14.1)具有相同的单加氧药物和异物代谢功能,其重要性被明显低估。本文在与CYP450进行对比的基础上,重点对FMO3的功能、变异、调控及应用等方面的最新进展进行了综述,并提出了进行FMO研究的未来策略。更多还原

【Abstract】 Flavin-containing monooxygenases (FMO) represent the second most important human monooxygenase system, after cytochrome P450. However, its importance is underestimated. This review summarized the distinctive characteristics of FMO3, including its function, genetic variation, regulation,application, etc. The population differences of FMO3 were also reviewed. Based on the above progress, the future strategy of FMO study in drug development was suggested.更多还原