【摘要】 目的探讨高尿酸血症与冠心病的关系。方法检测经冠脉造影确诊的冠心病患者75例与67例健康体检者的血尿酸(UA)、胆固醇(TC)、甘油三酯(TG)、血肌酐(Cr)、尿素氮(BUN)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,并将冠心病患者按两种方式分组:按稳定型心绞痛(SAP,n=24)、不稳定型心绞痛(UAP,n=29)、急性心肌梗死(AMI,n=22)分为三组;依据冠脉造影分为单支冠脉狭窄(Ⅰ组,n=25)、双支冠脉狭窄(Ⅱ组,n=26)、三支冠脉狭窄(Ⅲ组,n=24)三组,两种分组方式均就上述观察指标进行相关的统计学分析。结果冠心病组血尿酸水平显著高于对照组(P<0.01)。其它生化指标TC、TG、HDL-C、LDL-C、BUN、Cr与对照组比较差异也有显著性(P<0.01)。SAP、UAP、AMI三组间血尿酸比较差异有显著性(P<0.01);SAP组BUN水平显著低于UAP、AMI组(P<0.05);SAP组Cr水平显著低于AMI组(P<0.05),与UAP组比较无显著性差异(P>0.05);三组间其它指标TC、TG、HDL-C、LDL-C比较差异无显著性(P>0.05)。Ⅰ、Ⅱ、Ⅲ组间UA比较差异有显著性(P<0.01);Ⅱ、Ⅲ组的BUN水平显著高于Ⅰ组(P<0.05);Ⅲ组的Cr水平显著高于Ⅰ组(P<0.05);三组间TC、TG、HDL-C、LDL-C比较差异无显著性(P>0.05)。结论高尿酸血症是冠心病发病的一个重要危险因素,血尿酸水平升高预示着冠心病病情加重。更多还原

【Abstract】 Objective To explore the relationship between hyperuricemia and coronary heart disease.Methods 142 patients with suspected CHD were divided into two groups according to the results of coronary ateriography:CHD group(n=75)and control group(n=67).The patients serum UA、TC、TG、HDL-C and LDL-C were detected by the standard method.CHD group were divided into diffrent groups by two ways: SAP,UAP and AMI groups;1,2 and 3-vessel disease according to coronary ateriography,which is Ⅰ,Ⅱ and Ⅲ groups.Results Serum UA level was elevated significantly in CHD group(P<0.01),and TC、TG、BUN、Cr 、HDL-C and LDL-C have also statistical difference between the two groups(P<0.01).In SAP、UAP and AMI groups,serum UA were statistical difference(P<0.01).SAP group serum BUN level significantly lower than that of UAP and AMI group(P<0.05),and serum Cr level significantly lower than that of AMI group(P<0.05).While other index have no statistical difference(P>0.05).There was statistical difference in Ⅰ,Ⅱand Ⅲ group,compared with serum UA level(P<0.01).Ⅲ group serum Cr level significantly higher than that of I group(P<0.05).while others,TC、TG、HDL-C and LDL-C have no statistical difference(P>0.05).Conclusion Hyperuricemia was an important risk factor in CHD.The level of UA was positively associated with the severity of CHD.更多还原