【摘要】 以中草药有效成分β-榄香烯为起始原料,在碱性条件下与氨基化的聚乙二醇（PEG）反应合成了一系列β-榄香烯单取代PEG衍生物,利用IR,¹H NMR及¹³C NMR对其结构进行了表征.并采用WST-1法观察其对人宫颈癌细胞（Hela）、人白血病细胞（K562）的抑制作用,探讨其体外抗肿瘤活性.细胞实验结果表明经PEG修饰的β-榄香烯的抗癌活性有不同程度的增强.更多还原

【Abstract】 A series ofβ-elemene monosubstituted polyethylene glycol（PEG）derivatives were prepared by the reaction ofβ-elemene with aminated PEG and characterized by IR,¹H NMR and ¹³C NMR spectra.Their in vitro antiproliferative activities towards K562 cell and Hela cell lines were evaluated by a WST-1 method, showing that their antiproliferative activities were improved compared to that ofβ-elemene.更多还原