【摘要】 目的探讨非小细胞肺癌(肺癌)中糖原合成酶激酶3(GSK-3)和癌胚抗原(CEA)的表达与肺癌临床病理的关系。方法用免疫组化法检测90例肺癌的GSK-3β、CEA表达水平。结果肺腺癌GSK-3β阳性率明显高于鳞癌(P<0.05),临床Ⅲ-Ⅳ期阳性率显著高于Ⅰ-Ⅱ期(P<0.05)。周围型肺癌CEA阳性率显著高于中央型肺癌(P<0.01),有淋巴结转移者阳性率显著高于无淋巴结转移者(P<0.05))。肺癌中GSK-3β与CEA表达呈正相关(P<0.05)。结论GSK-3β促进肺癌的演进过程,与肺癌的分化、分期相关。肺癌高表达CEA时癌组织异质性粘附增加,有利于其浸润与转移。肺癌GSK-3β与CEA表达呈正相关。更多还原

【Abstract】 Objective To study the expression of glycogen synthase kinase-3(GSK-3β)and carcinoembryonic antigen(CEA)in non-small cell lung cancer(NSCLC)and evaluate their relationship with clinic pathological factors.Methods The expressions of GSK-3β and CEA were examined by immunohistochemical technique in 90 cases with NSCLC.Results The positive rate of GSK-3β in adenocarcinoma was significantly higher than that in squamous cell lung cancer(P<0.05).The positive rate of GSK-3β in clinical Ⅲ-Ⅳ stage patients was significantly higher than that in Ⅰ-Ⅱ stage(P<0.05).The positive rate of CEA in peripheric lung cancer was significantly higher than that in central lung cancer(P<0.01).The positive rate of CEA in the lung cancer with lymph node metastasis was significantly higher than that in the lung cancer without metastasis(P<0.05).Positive correlation was found between GSK-3β and CEA in NSCLC(P<0.05).Conclusion GSK-3β provotes the development of lung cancer,and is correlated with its differentiation and clinical stage.The overexpression of CEA enhances heterogeneous adhesion in lung cancer,which facilitates its invasion and metastasis.The expression of GSK-3β and CEA is positively correlated in lung cancer.更多还原