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脑缺血时乳酸的生成、转运、代谢和利用
Lactate production,metabolism,transportation and usage during cerebral ischemia
【摘要】 近年来对乳酸的研究表明,乳酸不仅是脑缺血/缺氧的代谢产物,同时也担负起在特殊情况下对神经元的供能作用。其主要在星形胶质细胞产生,又被神经元摄入胞内提供能量。此过程中单羧酸转运体(MCTs)充当着转运的角色。对乳酸的深入研究将有助于全面认识乳酸在脑缺血中的病理生理意义。
【Abstract】 Recent study has shown lactic acid (LA) is not only waste metabolite during cerebral-ischemia, but also energy supply for the neuron in the pathophyiological situation.LA is made mainly in neuronal aerobic, and in turn taken in neuron, in the way of transportation by monocarboxylate transporter(MCTs).It is helpful to understand LA pathophysiological significance with the further study of LA.
【基金】 教育部博士学科点专项科研基金资助项目(No20060003072);国家自然科学基金资助项目(No30572340,30500651)
- 【文献出处】 中国药理学通报 ,Chinese Pharmacological Bulletin , 编辑部邮箱 ,2008年03期
- 【分类号】R743
- 【被引频次】38
- 【下载频次】612