【摘要】 目的:评价CT灌注成像在肝纤维化中的作用。方法:建立家兔肝纤维化模型17只,分批分期行CT同层动态增强扫描,后取肝脏行病理检查,用去卷积数学方法中双输入-单室模型计算多个参数(肝动脉灌注量、门静脉灌注量、总肝灌注量、肝动脉灌注指数、分布容积、平均通过时间等),然后进行分组,用SPSS11.0统计软件分析。结果:发现CT灌注成像所有参数均无统计学差异,而仅仅表现为相对减少或增加的趋势。结论:CT灌注成像对肝纤维化的评价需进一步研究和探讨。更多还原

【Abstract】 Objective:To evaluate the role of CT perfusion imaging in the diagnosis of hepatic fibrosis.Methods:There were 17 rabbits involved in this study,carbon tetrachloride was injected intraperitoneally to make the model of rabbit liver fibrosis.The single-level dynamic CT scan was performed for control group and experimental groups in batch and by grade,then the changes of hepatic pathology was observed.CT perfusion parameters,including hepatic arterial perfusion,portal venous perfusion,total liver perfusion,hepatic arterial perfusion index,distribution volume,mean transit time,and so on,were calculated respectively with deconvolution method of dual in-put one-compartmental model.Statistical analysis was performed by SPSS 11.0 statistical software.Results:All parameters of CT perfusion were not statistical significant difference,there was only a trendency of increase or decrease in all parameters.Conclusion:CT perfusion imaging in the diagnosis of hepatic fibrosis needs to be studied further by investigators.更多还原