【摘要】 目的:探讨急性心力衰竭(HF)患者血浆B型尿钠肽(BNP)改变及其临床意义。方法:对48例HF患者(HF组)和50例健康者(对照组),行超声心动图检查测定左室射血分数(LVEF),同时测定血浆BNP水平,心衰患者治疗3～4周后复查超声心动图和BNP,观察治疗前后各指标的变化及BNP水平与LVEF的相关性。结果:(1)HF组血浆BNP水平明显高于对照组(P<0.01);(2)HF控制后BNP水平明显降低(P<0.01);(3)BNP浓度与LVEF有很好的相关性(P<0.01)。结论:血浆BNP水平对HF的诊断、严重程度和预后评价有重要价值。更多还原

【Abstract】 Objective:To study the clinical significance of the changes of plasma BNP1evels in patients with heart failure(HF).Methods:The plasma BNP levels in 48 patients with HF(NYNAⅡ、Ⅲ、Ⅳ)and 50 controls were determined with rapid fluorescence im-munoassay.Results:The plasma BNP levels in patients with HF were significantly higher than those in centrels(P<0.01).The plasma BNP level was low when HF was cured(P<0.01).The simple relative analysis indicated that the plasma BNP levels were negatively correlated to LVEF(r=-0.887,P<0.01).Conclusion:Determination of plasma BNP levels in patients with HF was helpful to the study of the severity and prognosis of disease.更多还原