【摘要】 目的:探讨氟西汀干预急性期脑卒中后康复的作用。方法:对新发卒中病人使用氟西汀干预,并根据随机双盲的原则分成氟西汀治疗组和常规治疗对照组。在1周和4周时分别检测神经功能缺损评分、抑郁量表值以及血浆和血小板5-羟色胺浓度。结果:治疗4周后治疗组的抑郁分值较对照组降低,神经功能康复差异有显著性(P<0.05),治疗组血小板5-羟色胺浓度低于对照组。结论:早期使用小剂量氟西汀能够减少卒中后抑郁,调节神经递质,促进患者神经功能的康复。更多还原

【Abstract】 Objective:To observe the effect of fluoxetine on functional recovery in poststroke patients and study its mechanism.Methods:The newly pathogenic patients with stroke were treated by fluoxetine or not comparatively.The evaluation of ADL,SSS and HAMD was scored at the first and fourth week after stroke.And at the same time the density of 5-HT was tested in plasma and platelet.Results:After using fluoxetine,the patients had good effects on fuctional recovery and reduced the rate of poststrock depression(PSD).But the density of platelet 5-HT in fluoxetine treatment group was lower compared to the other group.And two groups had no difference in that of plasma 5-HT.Conclusion:Using fluoxetine can reduce rate of PSD,modulate the neurotransmitter and improve the rehabilitation for poststroke patients.更多还原