【摘要】 目的:探讨血管内皮生长因子(VEGF)在乳腺癌中的表达及其临床意义。方法:应用免疫组织化学法检测74例乳腺癌组织中VEGF的表达。分析其与乳腺癌临床病理特征及预后的关系。结果:VEGF的阳性表达率为64.9%。VEGF的表达与肿瘤大小(P<0.05)、临床分期(P<0.05)、腋淋巴结转移(P<0.05)有关。VEGF表达阴性和阳性两组5年总生存率(overallsurvival,OS)和无瘤生存率(disease free survival,DFS)差异均有显著性(P<0.05)。结论:VEGF阳性表达提示乳腺癌预后不良。VEGF可为判断乳腺癌预后的有效指标。更多还原

【Abstract】 Objective:To investigate the expression of vascular endothelial growth factor (VEGF) in breast carcinoma and the clinical significance. Methods:74 women with primary breast carcinoma were studied for the expression of VEGF using immunohistochemical assay.The association of VEGF expression with clinical pathological characteristics and prognosis was further analyzed.Results:64.9% breast cancer cases were found with positive expression for VEGF.The expression of VEGF were related to tumor size(P<0.05),clinical stage(P<0.05) and lymph node metastasis(P<0.05).Both overall survival (OS) and disease free survival (DFS) were statistically significant between VEGF expression negative and VEGF expression positive respectively. Conclusion:VEGF expression may be a poor prognosis for human breast cancer.VEGF is an important prognostic factor in breast cancer.更多还原