【摘要】 目的探讨氟伐他汀对冠心病患者白细胞介互素-6(IL-6)、白细胞介素-10(IL-10)和基质金属蛋白酶-1(MMP-1)水平的影响。方法冠心病患者51例:急性心肌梗死(AMI)13例、不稳定型心绞痛(UAP)18例、稳定型心绞痛(SAP)20例;健康对照者20名。所有试验对象当天采集空腹静脉血5ml。冠心病患者随机分为2组:氟伐他汀40mg治疗组(26例)和80mg治疗组(25例),30d时再次采血5ml,测定IL-6、IL-10和MMP-1浓度。结果治疗前AMI、UAP组IL-6和MMP-1显著升高(P<0.01);两组治疗后IL-6和MMP-1均有明显下降(P<0.01),但80mg组下降更甚(P<0.01)。血清IL-6水平与血清MMP-1水平呈显著正相关(r=0.847,P<0.01)。IL-10在治疗前、后均无明显变化。结论IL-6、MMP-1在ACS患者中血清水平明显升高,可能与炎症反应、斑块不稳定相关,从而促进了冠心病患者发展为临床上的ACS;IL-10在冠心病患者血清水平中无明显变化;IL-6、MMP-1和IL-10与冠脉病变支数无关;氟伐他汀可能通过抑制IL-6、MMP-1的水平而发挥抗炎作用,其效用与药物浓度相关。更多还原

【Abstract】 Objective To examine the variance of IL-6, IL-10, MMP-1 in patients with coronary Heart diseases after treatment by Fluvastatin. Methods Serum concentrations of IL-6,IL-10 and MMP-1 were measured in 13 patients with acute myocardial infarction(AMI), 18 patients with unstable angina pectoris(UAP), 20 Patients with stable angina pectoris(SAP) and 20 controls by enzyme-linked immunosorbent assay(ELISA). 51 patients with CHD were randomly divided into 2 groups: 40 mg group and 80 mg group treated by FLuvastatin. The serum level of IL-6,IL-10 and MMP-1 were compared among all groups. Results Serum concentrations of IL-6, MMP-1 were significantly increasd in the AMI and UAP groups (P<0.01). The correlations of IL-6 and MMP-1 had significance(r=0.847,P<0.01). The serum level of IL-6 and MMP-1 were significantly decreasd after therapy(P<0.01). Conclusion Serum concentrations of IL-6 and MMP-1 increase in patients with acute coronary syndromes,and may be important to the instability of athero -sclerotic plaque. Serum concentrations of IL-10 had no variance among all groups. Serum concentrations of IL-6,IL-10 and MMP-1 had no relationships with coronary plaque extent. Fluvastatin can decrease serum level of IL-6 and MMP-1 in patients with CHD,and have a beneficial effect on steadying the plaque.更多还原