【摘要】 目的探讨代谢综合征(MS)对高血压患者血管内皮功能及颈动脉粥样硬化的影响。方法选取120例高血压患者,根据有无合并MS将其分为2组:MS组(65例)和非MS组(55例),彩色多普勒超声测定肱动脉反应性充血内径、颈动脉内膜厚度及斑块情况。选取健康体检者40名作为对照组(NC组)。结果①MS组的体重指数(BMI)、甘油三酯(TG)、空腹血糖(FPG)均高于非MS组和NC组,P<0.05,P<0.01。②内皮依赖性血管舒张功能(FMD%):MS组明显低于非MS组和NC组[(7.15±2.46)%、(8.45±4.13)%和(12.23±5.12)%,P均<0.05]。③三组颈动脉内膜厚度(IMT)依次为:(0.84±0.21)mm、(0.78±0.24)mm和(0.64±0.14)mm,P均<0.01;颈动脉斑块发生率依次为29.3%、21.8%和5.0%,P均<0.01。④相关分析显示,FMD%与年龄、SBP、TG、FPG呈负相关(r=-0.359、r=-0.357、r=-0.346、r=-0.413,P均<0.01),与HDL-C呈正相关(r=0.341,P<0.01);IMT与年龄、SBP、BMI、TG呈正相关(r=0.431,r=0.442,r=0.315,r=0.342,P均<0.01),与HDL-C呈负相关(r=-0.313,P<0.01)。结论并发MS可加重高血压患者血管内皮功能失调及促进颈动脉粥样硬化的发生。更多还原

【Abstract】 Objective To explore the damage of metabolic syndrome on endothelial function and carotid atherosclerosis in hypertensive patients. Methods Patients with essential hypertension(EH) were divided into two groups: with metabolic syndrome (MS group,n=65)and non MS group(n=55), and 40 healthy subjects as control group(NC). All cases were received echocardiography and carotid ultrasonography. Carotid intima-media thickness (IMT) and brachial artery diameter reactive hyperemia were measured. Results ⑴Compared with the subjects without MS and NC group,the level of BMI,fasting plasma glucose(FPG), TG were higher in MS group,P<0.05,P<0.01.⑵Endothelium-dependent dilatation (FMD%) were significantly lower in MS group than in non MS and NC group([(7.15±2.46)% vs (8.45±4.13)% and(12.23±5.12)%,P<0.05].⑶IMT and the incidences of plaque were significantly higher than in non MS group and NC group(29.3% vs 21.8% and 5.0%,P<0.01. ⑷FMD% was negatively correlated with age, SBP,TG,FPG(r=-0.359,r=-0.357,r=-0.346,r=-0.413,P<0.01),and positively correlated with H-DLC(r=0.341,P<0.01). IMT was positively correlated with age,SBP,BMI,TG(r=0.431,r=0.442,r=0.315,r=0.342,P<0.01). Conclusion Metabolic syndrome further aggravated vascular dysfunction and carotid atherosclerosis in patients with essential hypertension.更多还原