【摘要】 目的探讨脑钠素(BNP)和水通道蛋白-2(AQP2)在原发性高血压发病机制中所起的作用。方法采用间接ELISA检测尿液AQP2浓度,用ELISA法检测血浆BNP浓度,并监测平均动脉压(MAP),分析各级高血压患者尿中AQP2浓度变化及其与血浆BNP浓度、MAP之间的关系。结果①左室肥厚组(LVH组)患者尿液AQP2浓度和血浆BNP浓度较健康对照组和无左室肥厚组(NLVH组)升高(P均<0.01),且各亚组这两个指标随着血压的升高而增高,各亚组之间比较差异有统计学意义(P<0.01)。②NLVH组尿液AQP2浓度和血浆BNP浓度高于对照组(P均<0.05),但与血浆BNP浓度、血压水平无明显相关性(P>0.05)。结论①BNP的检测有利于EH合并LVH早期诊断;②BNP有可能通过细胞信使分子之间的相互作用影响AQP2的表达。更多还原

【Abstract】 Objective To incesting the effects of (p-BNP) and (u-AQP2) in EH’s pathogenesy. Methods In all subjects, the concentration of u-AQP2 were detected by indirect enzyme linked immunosorbent assay(indirect ELISA), the plama concentration of BNP were detected by enzyme linked immunosorbent assay(ELISA),and the mean arterial pressure(MAP) was measured,then discuss the relationship among u-AQP2,p-BNP and MAP. Results ⑴The concentration of u-AQP2(P<0.01) and p-BNP(P<0.01) in the patients with LVH were higher than that in control subjects and the patients with NLVH. The concentration of u-AQP2 and p-BNP in the patients in the three different subgroups with LVH were higher than that in control subjects and the patients with NLVH in the same blood pressure grade(P<0.01),that inceased along with the blood pressure grade(P<0.01). ⑵The concentration of u-AQP2(P<0.05) and p-BNP(P<0.05) in the patients with NLVH were higher than that in control subjects. Though the concentration of u-AQP2 and p-BNP in the patients in the three different subgroups with NLVH were higher than that in control subjects, there is no correlation among the three different subgroups(P>0.05). Conclusion ⑴The concentration of u-AQP2 in the patients with LVH were increases,.It suggests that the test of BNP was beneficial for the diagnosis of EH with LVH;⑵The concentration of p-BNP in the patients with LVH were significantly increases and had positive correlation with u-AQP2 and MAP. It suggests that BNP has effected the expression of AQP2 by mutually effect of cecular messenger molecule;.3. The concentration of u-AQP2 in the patients with NLVH were higher than that in control subjects,but it had no correlation with p-BNP and MAP.更多还原