【摘要】 目的观察血红素氧合酶-1(HO-1)与高血压患者血压的关系。方法选择确诊高血压病患者200例,分为:①低度危险组80例;②中度危险组50例;③高度危险组40例;④极高危险组30例;选择在读健康学生30名作为对照组。先利用t检验比较对照组与试验组HO-1表达的不同,再利用方差分析及Q检验比较4组高血压病患者HO-1表达的差异,找出HO-1与高血压病严重程度的关系。利用免疫组化方法和Western Blot检测高血压病患者外周血单个核细胞中HO-1的表达水平。结果高血压患者极高危险组HO-1表达明显高于高血压病患者低度危险组(P<0.01)。结论HO-1的表达水平与高血压病严重程度有关。更多还原

【Abstract】 Objective To investigate the changes of heme oxygenase-1 in patients with hypertension.Methods The patients with hypertension(n=200) were divided into 4 groups:low degree danger group(n=80) medium degree danger group (n=50) high danger group(n=40) and very high danger group(n=30),and control group(n=30).The levels of HO-1 protein expression of monocyte and lymphocyte in patients were tested by immunohistochemistry and Western Blot. Results The level of HO-1 protein expression in patients with hypertension of very high danger were significantly higher than that in hypertension of low degree danger(P<0.01).Conclusion The level of HO-1 protein expression is associated with types of hypertension.更多还原