【摘要】 目的:探讨急性冠脉综合征(ACS)患者血基质金属蛋白酶(MMP)2和9含量的变化及其培哚普利的的干预影响。方法:选择60例健康人做对照,60例ACS患者随机被分为常规治疗组(n=30例)和培哚普利治疗组(n=30例),治疗3周,治疗前、后测量血清MMP-2和MMP-9含量的变化。结果:ACS患者血清MMP-2,9含量显著高于健康对照组(P<0.01);培哚普利组血清MMP-9含量显著低于常规治疗组(P<0.05)。结论:培哚普利能够抑制基质金属蛋白酶9的分泌。更多还原

【Abstract】 Objective:To investigate the effects of perindopril on serum level of metric metalloprotease-2(MMP-2) and metalloprotease-9(MMP-9) in patients with acute coronary syndromes(ACS).Methods:The 60 healthy people were selected as the control group, 60 ACS patients were randomly divided into two groups: conventional therapy group (n=30), perindopril group(treated with perindopril on the basis of convectional therapy for three weeks,n=30).Before and after treatment the serum level of MMP-2 and MMP-9 were detected.Results:The serum level of MMP-2 and MMP-9 in ACS group was higher than those of healthy control group(P<0.01) .After treatment, the serum level of MMP-2 and MMP-9 in perindopril group significantly decreased(P<0.05) and the MMP-9 level decreased more than that of control group(P<0.05).Conclusion:Perindopril can decreases the biosynthesis of MMP-9 .更多还原