【摘要】 心肌纤维化是多种心脏病的共同病理基础。目前研究表明转化生长因子和肝细胞生长因子分别促进和抑制心肌纤维化,其共同的下游因子—结缔组织生长因子,在介导两者正负调控心肌纤维化过程中起重要作用,从而为相关的心脏疾病指引新的治疗方向。本文综述了该领域研究的最新进展。更多还原

【Abstract】 Myocardial fibrosis is the common pathological basis of several cardiac diseases.It is now well known that transforming growth factor-β1 and hepotocyte growth factor respectively promote and inhibit myocardial fibrosis,their mutual downstream-connective tissue growth factor,is important for mediation of positive and negative regulation in myocardial fibrosis,thus it shows new ways to treat cardiac diseases. Some recent advancements of this area reviewed in this article.更多还原