【摘要】 人类果蝇相关基因——HERG是从人类海马cDNA文库中鉴定出来,与果蝇EAG基因具有同源性。HERG基因编码延迟整流钾通道的α亚单位,这一类钾通道属电压依赖性通道。实验研究发现HERG基因突变引起其编码的通道结构及功能改变,从而引起心肌细胞动作电位时程改变,临床上表现为心律失常。HERG基因已被证实与心律失常发病有关,尤其是与长QT综合征LQT2的发生有密切关系。现就HERG基因的结构,HERG钾通道的结构、特性及其与心律失常的关系作一综述。更多还原

【Abstract】 Human ether-a-go-go-related gene(HERG),which was identified from the cDNA library of human hippocampus,has homology with the EAG gene in the Drosophila.HERG has now been shown to encode the α subunit of the delayed rectification potassium channel that is belong to the voltage-dependent potassium channel family.Researchers have determined that the changes in the structures and functions of the channel,caused by a gene mutation of HERG,alter the action potential duration of the myocardial cells,thus displaying the manifestation of arrhythmia.Nowadays,it has been that HERG has something to do with the onset of arrhythmia,especially the long QT syndrome 2.This article provides an overview of the structure of the gene and the channel,the property of this potassium channel and its connection with the occurrence of arrhythmia.更多还原