【摘要】 目的探讨p14ARF、mdm2、p53蛋白在鼻咽癌中的表达及其意义。方法应用免疫组化法检测58例鼻咽癌组织和20例慢性鼻咽炎症组织中p14ARF、mdm2、p53蛋白的表达情况。结果p14ARF、mdm2、p53蛋白在鼻咽癌组织和慢性鼻咽炎症组织中的阳性表达率分别为31.0%、41.4%、65.5%和100%、0、0,各个蛋白在两组之间表达的差异有统计学意义(P<0.05)。结论p14ARF蛋白低表达以及mdm2、p53蛋白高表达与鼻咽癌有关。更多还原

【Abstract】 Objective To investigate the role of p14ARF,mdm2,p53 protein in the process of carcinogenesis of nasopharyngeal carcinoma.Methods Expression of p14ARF,mdm2 and p53 protein were detected by immunohisto-chemical methods in 78 formalin-fixed and paraffin-embedded tissues,including nasopharyngeal carcinoma(n=58),chronic nasopharyngitis(n=20).Results positive rates of p14ARF,mdm2,p53 in patients with nasopharyngeal carcinoma and chronic nasopharyngitis were 31.0%、41.4%、65.5% and 100%,0,0,respectively.Expression of p14ARF protein were significantly decreased and mdm2,p53 protein were significantly elevated in nasopharyngeal carcinoma compared with chronic nasopharyngitis(P<0.05).Conclusion The results suggested that p14ARF-mdm2-p53 cell cycle regulation pathway may play important roles in carcinogenesis of nasopharyngeal carcinoma and may be valuable markers in nasopharyngeal carcinoma diagnosis and therapy.更多还原