【摘要】 目的比较2种黏弹剂(透明质酸钠和DuoVisc)在白内障超声乳化手术中对角膜内皮细胞的影响。方法选择我院就诊的老年性白内障患者72例86眼,按选用的黏弹剂不同,随机分为2组:透明质酸钠组和DuoVisc组,均采用超声乳化术摘出白内障,同时植入折叠型人工晶状体。术前、术后1周、4周、12周分别测量角膜内皮细胞并计数,进行统计学分析。结果术前角膜内皮细胞计数:透明质酸钠组(2 601.5±191.2)mm-2和DuoVisc组(2 579.6±232.0)mm-2,经比较差异无统计学意义。术后1周、4周、12周DuoVisc组的角膜内皮细胞平均计数分别为(2 371.5±215.3)mm-2、(2 377.8±220.6)mm-2、(2 416.3±213.2)mm-2高于透明质酸钠组(2 098.1±151.4)mm-2、(2 189.7±147.6)mm-2、(2 219.4±151.2)mm-2,差异有统计学意义(P<0.01)。术后不同时间DuoVisc平均角膜内皮细胞丢失量均低于透明质酸钠组。结论白内障超声乳化手术中DuoVisc对角膜内皮细胞的保护能力高于透明质酸钠。更多还原

【Abstract】 Objective To compare the ability of sodium hyaluronate and DuoVisc to protect the corneal endothelium during endocapsular phacoemulsification and foldable intraocular lens implantation.Methods Seventy-two cases(86 eyes) with age-related cataract were selected and divided randomly to two groups,sodium hyaluronate group and DuoVisc group,according to the viscoelastic material.Cataract was excluted with phacoemulsification and folded intraocular lens were implanted.Endothelial cell counts were done preoperatively and 1 week,4 weeks,and 12 weeks postoperatively using noncontact endothelial microscope.The data were statistically analyzed.Results The average cell density in corneal endothelium of the sodium hyaluronate group and the DuoVisc group were (2 601.5±191.2)mm-2 and(2 579.6±232.0)mm-2,respectively,in preoperation.There was no significant difference between both two groups.At 1 week,4 weeks and 12 weeks postoperatively,the average cell density in corneal endothelium of the DuoVisc group were (2 371.5±215.3)mm-2,(2 377.8±220.6)mm-2,(2 416.3±213.2)mm-2 respectively,and the sodium hyaluronate group was (2 098.1±151.4)mm-2,(2 189.7±147.6)mm-2,(2 219.4±151.2)mm-2.It was obvious that the former was higher and the difference was significant(P<0.01).Conclusion DuoVisc is better than sodium hyaluronate for protecting corneal endothelial cells in cataract phacoemulsification.更多还原